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DNA methylation and histone modifications regulate SOX11 expression in lymphoid and solid cancer cells.

Författare:
  • Lena Nordström
  • Elin Andersson
  • Venera Kuci
  • Elin Gustavsson
  • Karolina Holm
  • Markus Ringnér
  • Per Guldberg
  • Sara Ek
Publiceringsår: 2015
Språk: Engelska
Publikation/Tidskrift/Serie: BMC Cancer
Volym: 15
Nummer: 1
Dokumenttyp: Artikel i tidskrift
Förlag: BioMed Central

Abstract english

The neural transcription factor SOX11 is present at specific stages during embryo development with a very restricted expression in adult tissue, indicating precise regulation of transcription. SOX11 is strongly up-regulated in some malignancies and have a functional role in tumorgenesis. With the aim to explore differences in epigenetic regulation of SOX11 expression in normal versus neoplastic cells, we investigated methylation and histone modifications related to the SOX11 promoter and the possibility to induce re-expression using histone deacetylase (HDAC) or EZH2 inhibitors.

Keywords

  • Cancer and Oncology

Other

Published
  • ISSN: 1471-2407
Markus Ringnér
E-post: markus [dot] ringner [at] biol [dot] lu [dot] se

Forskningsingenjör

Molekylär cellbiologi

B-A317

Sölvegatan 35, Lund

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