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High Myc pathway activity and low stage of neuronal differentiation associate with poor outcome in neuroblastoma.

Författare:
  • Erik Fredlund
  • Markus Ringnér
  • John M Maris
  • Sven Påhlman
Publiceringsår: 2008
Språk: Engelska
Sidor: 14094-14099
Publikation/Tidskrift/Serie: Proceedings of the National Academy of Sciences
Volym: 105
Nummer: 37
Dokumenttyp: Artikel i tidskrift
Förlag: National Acad Sciences

Abstract english

The childhood cancer neuroblastoma arises in the developing sympathetic nervous system and is a genotypically and phenotypically heterogeneous disease. Prognostic markers of poor survival probability include amplification of the MYCN oncogene and an undifferentiated morphology. Whereas these features discriminate high- from low-risk patients with precision, identification of poor outcome low- and intermediate-risk patients is more challenging. In this study, we analyze two large neuroblastoma microarray datasets using a priori-defined gene expression signatures. We show that differential overexpression of Myc transcriptional targets and low expression of genes involved in sympathetic neuronal differentiation predicts relapse and death from disease. This was evident not only for high-risk patients but was also robust in identifying groups of poor prognosis patients who were otherwise judged to be at low- or intermediate-risk for adverse outcome. These data suggest that pathway-specific gene expression profiling might be useful in the clinic to adjust treatment strategies for children with neuroblastoma.

Keywords

  • Cancer and Oncology

Other

Published
  • CREATE Health
  • ISSN: 1091-6490
Markus Ringnér
E-post: markus [dot] ringner [at] biol [dot] lu [dot] se

Forskningsingenjör

Molekylär cellbiologi

B-A317

Sölvegatan 35, Lund

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