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An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours

Författare:
  • P. Mestdagh
  • Erik Fredlund
  • F. Pattyn
  • A. Rihani
  • T. Van Maerken
  • J. Vermeulen
  • C. Kumps
  • B. Menten
  • K. De Preter
  • A. Schramm
  • J. Schulte
  • R. Noguera
  • G. Schleiermacher
  • I. Janoueix-Lerosey
  • G. Laureys
  • R. Powel
  • D. Nittner
  • J-C Marine
  • Markus Ringnér
  • F. Speleman
  • J. Vandesompele
Publiceringsår: 2010
Språk: Engelska
Sidor: 3583-3592
Publikation/Tidskrift/Serie: Oncogene
Volym: 29
Nummer: 24
Dokumenttyp: Artikel i tidskrift
Förlag: Nature Publishing Group

Abstract english

Different classes of non-coding RNAs, including microRNAs, have recently been implicated in the process of tumourigenesis. In this study, we examined the expression and putative functions of a novel class of non-coding RNAs known as transcribed ultraconserved regions (T-UCRs) in neuroblastoma. Genome-wide expression pro. ling revealed correlations between specific T-UCR expression levels and important clinicogenetic parameters such as MYCN amplification status. A functional genomics approach based on the integration of multi-level transcriptome data was adapted to gain insights into T-UCR functions. Assignments of T-UCRs to cellular processes such as TP53 response, differentiation and proliferation were verified using various cellular model systems. For the first time, our results de. ne a T-UCR expression landscape in neuroblastoma and suggest widespread T-UCR involvement in diverse cellular processes that are deregulated in the process of tumourigenesis. Oncogene (2010) 29, 3583-3592; doi:10.1038/onc.2010.106; published online 12 April 2010

Keywords

  • Cancer and Oncology
  • non-coding RNA
  • neuroblastoma
  • T-UCR

Other

Published
  • ISSN: 1476-5594
Markus Ringnér
E-post: markus [dot] ringner [at] biol [dot] lu [dot] se

Forskningsingenjör

Molekylär cellbiologi

B-A317

Sölvegatan 35, Lund

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