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Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays

Författare:
  • Johan Staaf
  • David Lindgren
  • Johan Vallon-Christersson
  • Anders Isaksson
  • Hanna Goransson
  • Gunnar Juliusson
  • Richard Rosenquist
  • Mattias Höglund
  • Åke Borg
  • Markus Ringnér
Publiceringsår: 2008
Språk: Engelska
Publikation/Tidskrift/Serie: Genome Biology
Volym: 9
Nummer: 9
Dokumenttyp: Artikel i tidskrift
Förlag: BioMed Central

Abstract english

We present a strategy for detection of loss-of-heterozygosity and allelic imbalance in cancer cells from whole genome single nucleotide polymorphism genotyping data. Using a dilution series of a tumor cell line mixed with its paired normal cell line and data generated on Affymetrix and Illumina platforms, including paired tumor-normal samples and tumors characterized by fluorescent in situ hybridization, we demonstrate a high sensitivity and specificity of the strategy for detecting both minute and gross allelic imbalances in heterogeneous tumor samples.

Keywords

  • Cancer and Oncology
  • Medical Genetics
  • Hematology

Other

Published
  • CREATE Health
  • ISSN: 1474-7596
Markus Ringnér
E-post: markus [dot] ringner [at] biol [dot] lu [dot] se

Forskningsingenjör

Molekylär cellbiologi

B-A317

Sölvegatan 35, Lund

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