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A method for finding putative causes of gene expression variation

  • Reija Autio
  • Sampsa Hautaniemi
  • Markus Ringnér
  • Päivikki Kauraniemi
  • Henrik Edgren
  • Olli Yli-Harja
  • Jaakko Astola
  • Anne Kallioniemi
  • Olli-Pekka Kallioniemi
  • Tommi Aho
  • Harri Lähdesmäki
  • Olli Yli-Harja
Publiceringsår: 2004
Språk: Engelska
Sidor: 29-30
Publikation/Tidskrift/Serie: TICSP Series
Volym: 24
Dokumenttyp: Konferensbidrag
Förlag: Tampere University of Technology

Abstract english

The majority of microarray studies evaluate gene ex-

pression differences between various specimens or con-

ditions. However, the causes of this variability often re-

main unknown. Our aim is to identify underlying causes

of these patterns, a process that would eventually enable

a mechanistic understanding of the deregulation of gene

expression in cancer. The procedure consists of three

phases: pre-processing, data integration and statistical

analysis. We have applied the strategy to identify genes

that are overexpressed due to amplification in breast

cancer. The data were obtained from 14 breast cancer

cell lines, which were subjected to cDNA microarray

based copy number and expression experiments. The re-

sult of the analysis was a list that consisted of 92 genes.

This set includes several genes that are known to be both

overexpressed and amplified in breast cancer. The com-

plete study was published in Journal of the Franklin In-

stitute 2004, and in this paper we focus on the main

issues of the study.


  • Biophysics


2nd TICSP Workshop on Computational Systems Biology, WCSB'2004
2004-06-14 - 2004-06-16
Silja Opera, Helsinki-St. Petersburg
  • ISSN: 1456-2774
  • ISBN: 952-15-1204-0
Markus Ringnér
E-post: markus [dot] ringner [at] biol [dot] lu [dot] se


Molekylär cellbiologi


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