Meny

Javascript verkar inte påslaget? - Vissa delar av Lunds universitets webbplats fungerar inte optimalt utan javascript, kontrollera din webbläsares inställningar.
Du är här

Associations between malaria and MHC genes in a migratory songbird

Författare:
  • Helena Westerdahl
  • Jonas Waldenström
  • Bengt Hansson
  • Dennis Hasselquist
  • Torbjörn von Schantz
  • Staffan Bensch
Publiceringsår: 2005
Språk: Engelska
Sidor: 1511-1518
Publikation/Tidskrift/Serie: Royal Society of London. Proceedings B. Biological Sciences
Volym: 272
Nummer: 1571
Dokumenttyp: Artikel i tidskrift
Förlag: Royal Society

Abstract english

Malaria parasites are a widespread and species-rich group infecting many wild populations of mammals, birds and reptiles. Studies on humans have demonstrated that genetic factors play a key role in the susceptibility and outcome of malaria infections. Until the present study, it has not been examined whether genetic variation in hosts is important for the outcome of malaria infections in natural avian populations. We investigated associations between major histocompatibility complex (MHC) genes and prevalence of three different avian malaria parasites (Haemoproteus payevshyi (GRW1), Plasmodium sp. (GRW2) and Plasmodium sp. (GRW4)) in a long-term study of great reed warblers Acrocephalus arundinaceus. We hypothesized that the MHC genes could either give full protection against a malaria infection, or confer protection against lethal malaria and direct the infection towards being milder. We found a positive association between numbers of MHC class I alleles (a measure of level of heterozygosity) and prevalence of the GRW2 parasite, suggesting the latter scenario. There was also a positive association between a specific MHC allele (B4b), previously shown to be under frequency-dependent selection in the study population, and prevalence of GRW2. These associations suggest that individuals carrying either a large number of MHC alleles or a specific MHC allele are protected against lethal malaria infections.

Keywords

  • Biological Sciences

Other

Published
  • Molecular Ecology and Evolution Lab
  • ISSN: 1471-2954
Bengt Hansson
E-post: bengt [dot] hansson [at] biol [dot] lu [dot] se

Professor

MEMEG

+46 46 222 49 96

+46 70 991 68 96

E-C210

Sölvegatan 37, Lund

50

Forskargrupp

Doktorander och postdocs

Huvudhandledare

Biträdande handledare

Postdocs