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Detecting Polygenic Evolution: Problems, Pitfalls, and Promises.

Författare:
  • Maren Wellenreuther
  • Bengt Hansson
Publiceringsår: 2016-01-21
Språk: Engelska
Publikation/Tidskrift/Serie: Trends in Genetics
Dokumenttyp: Artikel i tidskrift
Förlag: Elsevier

Abstract english

Unraveling the genetic basis of organismal form and function remains one of the major goals of evolutionary biology. Theory has long supported a model of polygenic evolution in which quantitative traits are underpinned by many genes of small effect, but empirical methods have lacked the power to detect causative loci when effect sizes are small or moderate. We (i) review traditional approaches used for identifying the molecular basis of phenotypic traits, to highlight the inherent problems and pitfalls that bias them towards the detection of large-effect loci. We then (ii) outline the promises of recent statistical frameworks to detect polygenic signatures of trait evolution, and discuss some of the first studies in evolutionary biology employing these approaches. Lastly, we (iii) outline future directions and point to areas that still need development.

Keywords

  • Evolutionary Biology
  • Genetics

Other

Published
  • Molecular Ecology and Evolution Lab
  • ISSN: 1362-4555
Bengt Hansson
E-post: bengt [dot] hansson [at] biol [dot] lu [dot] se

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